De la Fuente was born in Santiago, Chile, as the only child of chemist Hugo de la Fuente and Adriana Sabarots, a homemaker of French descent. He served in the Chilean Air Force reserve prior to attending the Pontifical Catholic University of Chile, where he pursued a degree in civil engineering. While still a sophomore, de la Fuente was discovered by a talent scout and encouraged to enter the country’s Super Teen contest, which he won. This was soon followed by roles in several telenovelas, including Eclipse de Luna, as well as, a stint as host of Chile’s top-rated variety series, Venga Conmigo.
Beginning with small network roles in prime time, De La Fuente quickly went on to star in four prime time dramas including Eclipse de Luna and the highly acclaimed televised theatrical production of La Tía de Carlos. He starred in Chile's number-one rated variety program Venga Conmigo (Come With Me), the comedy Mi Tío y Yo (My Uncle and Me) and the MTV-style music and dance program Generación 2000 (Generation 2000).
His starring role in the independent thriller Minimal Knowledge, won him the Individual Achievement Award for Best Male Actor at the Ajijic (Mexico) International Film Festival.
In 2005, he starred in the Venevisión's Miami-made telenovela Soñar No Cuesta Nada, starring alongside Mexican actresses Karyme Lozano and Laura Zapata. It was a huge hit in the daytime slot on Univisión. It ran about 191 episodes and 9 months on air. De la Fuente was also seen in his supporting role, in the indie romantic drama Sueno with John Leguizamo and the Latin-themed comedy Once Upon a Wedding. The busy actor also found time to appear in a recurring role on the CBS comedy The Class in 2006, and an episode of the wildly popular ABC show Ugly Betty. In the fall 2007, he participated in the mini series directed by Jennifer Lopez Como Ama Una Mujer with the actress Leonor Varela.
De la Fuente was a series regular on CBS’S Family Law, NBC’S Gated Community and Bad Girls Guide, on UPN. He had recurring roles on: UPN’S One on One, CBS’S CSI: Miami, and NBC’S Hidden Hills. On ABC he guest starred as Kelly Ripa’s love interest on Hope and Faith. He played an AFI agent on Threat Matrix and co-starred opposite Kim Delaney in the MOW Infidelity. He was a series lead on the Episodic Reyes Y Rey for Sony/Telemundo.
In 2010, de la Fuente’s book with writer/producer Federico Larino, Hot, Passionate and Illegal: Why (Almost) Everything You Thought About Latinos Just May Be True lend personal and hilarious experiences as a Latino in Hollywood to dispel common myths and admit the sometimes embarrassing yet always endearing truths about this culture.
He was the first male to grace the cover of Cosmopolitan En Espanola, and was named one of the 50 most beautiful by People Magazine En Espanol four times and in 1999 in People Magazine USA. He was one of TV Guides 2009 “Sexiest TV Stars.”
Cristián resides in LA with his wife Angelica Castro and their daughter.