Nolasco is a native of Puerto Rico and studied biology while attending the University of Puerto Rico. His plan to enroll in medical school was cut short when a director approached Nolasco, and encouraged him to pursue acting. He was immediately cast in his first television commercial and began working consistently as an actor in Puerto Rico.
Eventually, Nolasco moved to New York and studied at the American British Dramatic Arts School. Shortly thereafter, he guest starred on several TV shows including, CSI: Crime Scene Investigation, George Lopez and CSI: New York.
Nolasco landed his first major supporting role in the film, 2 Fast 2 Furious, as "Orange Julius." He went on to costar in several more films including, Mr. 3000 opposite Bernie Mac, and Benchwarmers opposite Rob Snieder and David Spade.
Most recently Nolasco co-starred in Michael Bay's Transformers, and David Ayer's Street Kings opposite Keanu Reeves, Forrest Whitaker, and Hugh Laurie. He also appeared opposite Mark Wahlberg in Max Payne.
In 2010, Nolasco’s starred in the film, the Rum Diary with Johnny Depp due he will appear on the big screen in ARMORED opposite Lawrence Fishburne, Matt Dillon and Jean Reno. This fall, Nolasco joins the critically acclaimed cast of Southland as Regina King’s partner Rene Cordero.